University of Wisconsin–Madison

Tag: clinical trials

A Closer Look At The Lecanemab Clinical Trials

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In a special episode of Dementia Matters, Drs. Cynthia Carlsson and Sterling Johnson join the podcast to discuss what they know from lecanemab’s clinical trials following the U.S. Food and Drug Administration’s (FDA) accelerated approval, granted on January 6, 2023.

Guests: Cynthia Carlsson, MD, MS, director, Wisconsin Alzheimer’s Institute, and Sterling Johnson, PhD, leader, Wisconsin Registry for Alzheimer’s Prevention (WRAP), associate director, Wisconsin Alzheimer’s Disease Research Center and Wisconsin Alzheimer’s Institute

Introducing Lecanemab, the Latest Alzheimer’s Disease Drug to Receive FDA Accelerated Approval

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Host Nathaniel Chin, MD, gives an overview of the new Alzheimer’s treatment Leqembi (lecanemab), and highlights results from the second and third phases of its clinical trials. On January 6, 2023, the U.S. Food and Drug Administration (FDA) approved Leqembi (lecanemab-irmb) via the Accelerated Approval pathway for the treatment of Alzheimer’s disease.

Breaking Down Medicare’s Proposed Decision on Aducanumab and Monoclonal Antibody Treatments

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On January 11, the Centers for Medicare and Medicaid Services (CMS) announced its much-anticipated coverage proposal for monoclonal antibody treatments that target amyloid for the treatment of Alzheimer’s disease. According to the proposed policy, this class of drugs, which includes aducanumab, also known by the brand name Aduhelm, would be covered for people with Medicare only if they are enrolled in qualifying clinical trials. Dr. Jason Karlawish joins the podcast to discuss the recent proposal, share his reaction to the decision, and tell us how this coverage policy could impact the development of other Alzheimer’s disease treatments in the future.

Guest: Jason Karlawish, MD, co-director, Penn Memory Center, professor of medicine, medical ethics and health policy, and neurology, University of Pennsylvania

Nasal Vaccine for Alzheimer’s Disease Enters Clinical Trial

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In November 2021, Brigham and Women’s Hospital in Boston launched the first human trial of a nasal vaccine for Alzheimer’s disease. Nearly 20 years of research went into developing the vaccine, which uses the immune system to clear Alzheimer’s disease-related proteins from the brain. Lead researcher Dr. Howard Weiner joins the podcast to discuss the science behind the vaccine and how it could introduce new ways of treating other neurodegenerative diseases in the future.

Guest: Howard Weiner, MD, professor of neurology, Harvard Medical School, co-director, Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital

New Approaches Yield Promise for Future of Alzheimer’s Disease Drug Trials

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For decades, researchers from around the world have been working to find a cure for Alzheimer’s disease. Dr. Sanjay Asthana explains the challenges Alzheimer’s disease drug trials have faced and introduces us to new, promising approaches to stopping or delaying the disease.

Guest: Sanjay Asthana, MD, associate dean of gerontology, University of Wisconsin School of Medicine and Public Health, and director and founder, Wisconsin Alzheimer’s Disease Research Center

New Study Looks at Fish Oil for Alzheimer’s Disease Prevention in Veterans

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Veterans are at a higher risk for Alzheimer’s disease than the general population. A new clinical trial is looking at the effect prescription fish oil has on brain health in veterans and will determine whether the supplement could be used as an effective prevention treatment for the disease.

Guest: Cynthia Carlsson, MD, MS, geriatrician, William S. Middleton Memorial Veterans Hospital, and investigator, Wisconsin Alzheimer’s Disease Research Center