Unpacking the U.S. POINTER Study

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The U.S. POINTER study is one of the first large-scale, randomized controlled clinical trials to focus on how lifestyle interventions impact dementia risk and cognitive decline. On a special bonus episode of Dementia Matters, Dr. Laura Baker joins the podcast to explain how the clinical trial came to be, what it found and what the next chapter of lifestyle intervention research and clinical trials looks like. Guest: Laura Baker, PhD, professor, Gerontology and Geriatrics, Wake Forest University School of Medicine, principal investigator, U.S. POINTER Study

Navigating Difficult Conversations about Driving and Dementia

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Driving can be a sensitive topic as a person gets older, and especially so when someone begins experiencing cognitive decline or is diagnosed with dementia. How can family members and care partners discuss their concerns about a loved one’s ability to drive while still respecting their dignity, autonomy and independence? Dr. KJ Hansmann joins the podcast to share strategies for how to talk about a loved one’s driving habits and how to plan to help them stop driving as they navigate cognitive decline, as well as what signs to look out for when assessing their ability to drive and what resources are available for both those living with cognitive decline and their care partners. Guest: KJ Hansmann, MD, PhD, MPH, family medicine doctor, UW Health, assistant professor, department of family and community health, UW School of Medicine and Public Health, principal investigator, Driving Connections Lab

The Role of Social Work in Dementia Care

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People with dementia and their families see many different doctors and health care providers following a diagnosis. Some may be surprised to know that social workers play a role in dementia care as well. Jeni Synnes, a social worker at UW Health, joins the podcast to explain her role in a memory clinic, the support social workers provide for families and care partners, and what people should know before and after a memory assessment. Guest: Jeni Synnes, MSSW, LCSW, social worker, UW Health

Training for Clinical Trials with the IMPACT-AD Program

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Are you a researcher interested in getting involved in Alzheimer’s disease and related dementias (ADRD) clinical trials? The Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD, or IMPACT-AD, program brings investigators from around the world together for a week of professional development and education. IMPACT-AD co-directors Dr. Josh Grill and Dr. Rema Raman, as well as faculty member Dr. Maria Carrillo, join the podcast to explain what the program entails, their mission and more. Guests: Josh Grill, PhD, director, Institute for Memory Impairments and Neurological Disorders, professor, University of California, Irvine (UCI), co-director, IMPACT-AD, Rema Raman, PhD, co-director, IMPACT-AD, director, Biostatistics Section and Recruitment, Engagement, and Retention Section, Alzheimer’s Therapeutic Research Institute (ATRI), professor of neurology, University of Southern California (USC), and Maria Carrillo, PhD, chief science officer, medical affairs lead, Alzheimer’s Association, co-principal investigator, Alzheimer’s Network for Treatment and Diagnostics (ALZ-NET), co-principal investigator, Longitudinal Early-Onset Alzheimer’s Disease Study (LEADS)

UW–Madison experts to present at 2026 Alzheimer’s state conference

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Nathaniel Chin, MD, will present a keynote talk, and several experts from the University of Wisconsin School of Medicine and Public Health will lead workshops at this year's Alzheimer’s Association Wisconsin State Conference.

How Ultra‑Processed Foods Impact Your Overall Health

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Ultra-processed foods are a hot topic in the fields of health and nutrition, but what exactly are they and how do they impact our overall well-being? Dr. Beth Olson joins the podcast to explain what this term means, describe strategies for developing a balanced diet and share a preview of her upcoming Healthy Living with Mild Cognitive Impairment (MCI) presentation, “Unpacking Ultra-Processed Foods.” Guest: Beth Olson, PhD, associate professor of nutritional sciences, University of Wisconsin–Madison

On the Pulse: How Resting Heart Rate Improves a Dementia Risk Score’s Accuracy

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What if your heartbeat could help determine your dementia risk? The CAIDE dementia risk score has long helped clinicians estimate midlife risk for dementia using cardiovascular health factors, but its accuracy hasn’t been equal across populations. New research suggests that integrating resting heart rate meaningfully improves predictive performance across most racial groups. In this interview, Dr. Newman Sze and Shakiru Alaka join us to dig into how and why resting heart rate enhances CAIDE’s accuracy, what the data shows across different racial groups, and what this could mean for earlier, more equitable identification of dementia risk in both research and clinical settings. Guests: Newman Sze, PhD, professor of health sciences, Brock University, Canada Research Chair in Mechanisms of Health and Disease, and Shakiru Alaka, MS, senior analyst, Canadian Institute for Health Information, data scientist, Western University

Could Managing Four Common Health Conditions Slow Cognitive Decline from Alzheimer’s?

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Alzheimer’s disease isn’t always the only health condition a person faces, so how does treating other diseases impact the progression of Alzheimer’s? Researchers at the University of Arizona focused on four common health conditions – type two diabetes, hypertension, inflammation and dyslipidemia – which are known to increase the risk of developing Alzheimer’s disease, and set out to investigate whether those diagnosed with Alzheimer’s who received treatments for these four conditions also saw a delay in cognitive decline. Dr. Barb Bendlin joins the podcast to break down the findings from this research, as well as discuss the impact of personalized prevention strategies and combination therapies. Guest: Barbara Bendlin, PhD, professor, Division of Geriatrics and Gerontology, University of Wisconsin (UW) School of Medicine and Public Health, deputy director, UW Center for Health Disparities Research (CHDR)

Healthy Living with MCI program empowers participants across Wisconsin, globally

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The Healthy Living with Mild Cognitive Impairment (MCI) educational program is drawing strong participation and positive feedback, connecting people across Wisconsin and beyond with science-backed education on brain health, Alzheimer’s disease prevention strategies and practical tools and resources to support living well with MCI.

Taking Steps to Slow Decline: New Study Examines the Role of Physical Activity on Alzheimer’s Progression

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10,000 – that’s the magic number of steps often recommended for a healthy lifestyle. With recent research looking into whether that number is an accurate benchmark for health, could the number of steps taken per day have an impact on brain health and, specifically, cognitive decline? That’s precisely what a new study from Harvard Medical School and Mass General Brigham sought to examine, looking at how physical activity, specifically step count, impacted cognitive decline for those living with Alzheimer’s disease. Dr. Bri Breidenbach and Sarah Lose join the podcast to break down the results of this new study, as well as share what current research says about the effect of other kinds of physical activity, such as different intensity exercises, on the brain and Alzheimer’s progression. Guests: Bri Breidenbach, PhD, scientist, exercise physiologist, Okonkwo Lab, and Sarah Lose, MS, research program manager, exercise physiologist, Okonkwo Lab, UW School of Medicine and Public Health

Reflecting on 2025: The Impact of Gratitude on Brain Health

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As 2025 comes to an end, host Dr. Nathaniel Chin discusses the importance of gratitude for brain health and shares what he’s grateful for from this past year.

Top 5 ‘Dementia Matters’ Episodes of 2025

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In 2025, Dementia Matters featured more than 25 guests who discussed over 20 topics spanning caregiving strategies and the current research landscape. What episodes were the most popular of the year?

Talking TBI: The Impact of Traumatic Brain Injuries on Cognitive Decline

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Traumatic brain injuries (TBI) like concussions are not uncommon, especially in children and older adults. These injuries can have both short-term and lasting effects on the brain, but what about their impact on cognitive function? Dr. Deling He of UW–Madison’s Cognitive-Communication in Aging and Neurogenic Disorders Laboratory (CCANDL) lab joins the podcast to discuss her research on the connections between TBI, speech pathology and cognition and what her study findings mean for people with a history of TBI. Guest: Deling He, PhD, postdoctoral research associate, Cognitive-Communication in Aging and Neurogenic Disorders Laboratory, Department of Communication Sciences and Disorders, UW–Madison

How Occupational Therapists and Speech-Language Pathologists Support Cognitive Health

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When memory, thinking or communication changes begin, knowing where to turn for support can make all the difference. In this episode, we explore how two key health care specialties can help individuals and families meet those challenges with confidence. Sarah Gunderson, an occupational therapist, and Kari Esser, a speech-language pathologist, draw from their work supporting people experiencing a wide range of neurological conditions to walk us through the foundations of their specialties and their unique roles in mild cognitive impairment (MCI) and dementia care. Sarah and Kari also provide a preview of their upcoming talk, “Partnering with Your Healthcare Team,” as part of the 2025 Healthy Living with MCI education program. Guests: Sarah Gunderson, OT, occupational therapist, UW Health, and Kari Esser, MS, CCC-SLP, speech-language pathologist, UW Health

Study Finds COVID-19 Can Cause Build-up of Alzheimer’s-Related Proteins in Eyes and Brain

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What do COVID-19 brain fog and ophthalmology have to do with Alzheimer’s disease? There may be more connections than one might think. Dr. Sean Miller is one of the scientists behind a recent study that used retinal tissue to investigate the links between COVID-19 infections and the build-up of amyloid and other indicators of Alzheimer’s disease in the central nervous system. Dr. Miller joins the podcast to discuss his research and its implications for COVID and dementia diagnosis and treatments in the future. Guest: Sean Miller, PhD, research scientist, department of ophthalmology and visual science, Yale School of Medicine