University of Wisconsin–Madison

Tag: Alzheimer’s Disease

Study Shows APOE e4 Not Associated with Alzheimer’s Disease in American Indian Populations

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Researchers typically recognize the APOE e4 gene as a significant genetic risk factor for cognitive decline and dementia. However, a new study has found that the allele is not linked to neurodegeneration for all races and ethnic groups, specifically for American Indian populations. Dr. Astrid Suchy-Dicey joins the podcast to discuss her study, the importance of representation in Alzheimer’s disease research, hypotheses for why this allele isn’t a risk factor for all populations and what it means for research going forward. Guest: Astrid Suchy-Dicey, PhD, epidemiologist, assistant research professor, Washington State University, Institute for Research and Education to Advance Community Health (IREACH)

Incorporating Cultural Knowledge: Improving Alzheimer’s Disease Research for Veterans and Native Americans

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Dr. Cynthia Carlsson and Daniel A. King join the podcast to discuss some of the unique ways that Alzheimer’s disease affects Veterans and Native Americans. Their work at the Wisconsin Alzheimer’s Disease Research Center allows them to connect with people who are at higher risk for Alzheimer’s disease and help educate them on how to maintain brain health, both through Dr. Carlsson’s research and clinical practice and Mr. King’s outreach to Veterans and Native Americans. Discussing the importance of current outreach and educational efforts as well as what they’ve learned from engaging with Veterans and Native Americans, Dr. Carlsson and Mr. King describes how understanding different cultures and community experiences can help Alzheimer’s disease research better support underserved populations. Guests: Cynthia Carlsson, MD, MS, professor of medicine and Alzheimer’s disease researcher, University of Wisconsin School of Medicine and Public Health, geriatrician, William S. Middleton Memorial Veterans Hospital, and Daniel A. King, member of the Oneida Nation of Wisconsin, Veteran recruitment coordinator, Wisconsin Alzheimer’s Disease Research Center

Update on Blood Tests for Alzheimer’s Disease

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Research in the field of fluid biomarkers is leading to new developments in Alzheimer’s disease identification, including new tests that can predict Alzheimer’s based on biomarkers in blood. Ahead of his keynote address as part of Alzheimer's Disease & Related Dementias Research Day on April 5, 2022, Dr. Thomas Karikari joins the podcast to discuss his work with these new blood tests, how accurate they are, and what research needs to be done before they are made available for clinical use. Guest: Thomas Karikari, PhD, assistant professor, University of Gothenburg, University of Pittsburgh

Breaking Down Medicare’s Proposed Decision on Aducanumab and Monoclonal Antibody Treatments

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On January 11, the Centers for Medicare and Medicaid Services (CMS) announced its much-anticipated coverage proposal for monoclonal antibody treatments that target amyloid for the treatment of Alzheimer’s disease. According to the proposed policy, this class of drugs, which includes aducanumab, also known by the brand name Aduhelm, would be covered for people with Medicare only if they are enrolled in qualifying clinical trials. Dr. Jason Karlawish joins the podcast to discuss the recent proposal, share his reaction to the decision, and tell us how this coverage policy could impact the development of other Alzheimer’s disease treatments in the future. Guest: Jason Karlawish, MD, co-director, Penn Memory Center, professor of medicine, medical ethics and health policy, and neurology, University of Pennsylvania

Accessibility and Community: Bringing Alzheimer’s and Dementia Resources to the Latinx Community

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UsAgainstAlzheimer’s newly-released tool, BrainGuide, may seem like a simple questionnaire, but the project highlights a growing movement to make Alzheimer’s disease research and resources accessible to a broader range of communities. Released in 2021, BrainGuide is a one-of-a-kind resource that provides information about Alzheimer’s disease in English and Spanish through online and telephone questionnaires. Dr. Maria Mona Pinzon, a physician-scientist at the University of Wisconsin School of Medicine and Public Health and a consultant on BrainGuide, joins the podcast to discuss the impacts this project has had on educating the Latinx community about Alzheimer’s disease. Discussing the barriers and risks that the Latinx community face surrounding brain health, the ways to connect with the community through research, and her experience working on BrainGuide, Dr. Pinzon highlights the importance and impacts of community-tailored research and resources.  Guest: Maria Mona Pinzon, MD, MS, University of Wisconsin School of Medicine and Public Health

You Are What You Eat: Study of Diet and Brain Health Shows Cognitive Benefits from Cheese, Wine and Lamb

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A recent study of nearly 1,800 participants from the UK Biobank found that three dietary elements — cheese, wine, and lamb — may improve long-term cognitive outcomes in aging adults. Dr. Auriel Willette, assistant professor of food science and human nutrition at Iowa State University, joins the podcast to discuss these new findings linking diet and cognitive changes. In November 2020, Willette published a study in the Journal of Alzheimer’s Disease titled, “Genetic Factors of Alzheimer’s Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study,” where he and his team studied the effects of particular foods on a person’s brain health over time. As well as the findings surrounding cheese, wine, and lamb, they found that limiting salt intake was good for the brain, especially for those at risk for Alzheimer’s disease. Discussing the field of nutritional research, his prior work studying diet and brain health, and how these findings impact other recommended diets, Willette provides insight into how our current diets can impact our health and cognitive abilities later in life, allowing us to make better choices for the future. Guest: Auriel Willette, PhD, associate professor of food science and human nutrition, Iowa State University

Tackling Stigma and Alzheimer’s Disease within the AAPI Community

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Vince Tien and Dr. Dung Trinh join the podcast to discuss the many ways Alzheimer’s disease affects the Asian Americans and Pacific Islanders (AAPI) community. Vince Tien and Dr. Trinh both work as part of 360 Clinic, a multi-specialty medical group focused on telehealth services. With their experience in healthcare and telehealth services amidst the pandemic, Tien and Dr. Trinh describe the barriers and stigma that discourage the AAPI community from seeking help for dementia and the ways that we can dismantle those barriers.  Guests: Vince Tien, co-founder, CEO, 360 Clinic, and Dung Trinh, MD, chief medical officer, 360 Clinic

Better Now than Never: Quit Smoking to Reduce Your Risk for Alzheimer’s Disease

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Researchers have produced many studies on how smoking affects parts of the body, such as the lungs or heart, but what about the brain? In today’s podcast, Adrienne Johnson, PhD, discusses her research on cigarette smoking and risk for dementia and Alzheimer’s disease. As part of a 2021 study, she found a person’s risk for dementia and Alzheimer's disease can be affected by how recently they’ve smoked. Diving into her research, the effects of smoking on different communities, and resources to support current smokers as they quit, Dr. Johnson details the impact of smoking on the brain and her hopes to develop new interventions to motivate smokers to quit for good. Guest: Adrienne Johnson, PhD, assistant scientist at the University of Wisconsin Center for Tobacco Research and Intervention

From Studying to Living with Alzheimer‘s Disease: A Conversation with Dr. Daniel Gibbs

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Neurologist and author Daniel Gibbs, PhD, joins the podcast to discuss his recent book, A Tattoo on My Brain, which details his journey from treating Alzheimer’s disease clinically for 25 years to being diagnosed with early-stage Alzheimer’s. Dr. Gibbs discusses early signs he experienced and daily life with the disease, as well as thoughts on the recent FDA-approved treatment aducanumab (marketed as Aduhelm). Guest: Daniel Gibbs, PhD, neurologist

How Close Are We to Curing Alzheimer’s Disease?

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For our 100th episode of Dementia Matters, Nina Silverberg, PhD, director of the Alzheimer's Disease Research Centers (ADRC) Program at the National Institute on Aging (NIA), joins the podcast to offer an overview of the ADRC Program as well as insight into the state of Alzheimer’s Disease research and its future. The NIA funds more than 30 Alzheimer’s Disease Research Centers across the country, including the Wisconsin ADRC. Guest: Nina Silverberg, PhD, National Institute on Aging

How to Shape Your Brain Health and Reduce Your Risk for Alzheimer’s Disease

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Neuropsychologist and author Michelle Braun, PhD, joins the podcast to talk about lifestyle changes that can support brain health. “We have the ability to make our brain younger than our chronological age,” she says. Braun shares how and details strategies from her new book, High-Octane Brain: 5 Science-Based Steps to Sharpen Your Memory and Reduce Your Risk of Alzheimer’s. Hear about common misconceptions around aging, three possible brain health trajectories, and how to maximize your brain health. Guest: Michelle Braun, PhD, neuropsychologist and national leader in the field of brain health

Study Finds Air Pollution a Risk Factor for Alzheimer’s Disease

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Researchers at the University of California, San Francisco found that among older adults with cognitive impairment, the greater the air pollution in their neighborhood, the higher the likelihood of the presence of amyloid plaques in their brain. Lead researcher Leonardo Iaccarino, PhD, details his work examining air pollution and brain health outcomes and discusses possible ways individuals and society can lower the impact of air pollution on Alzheimer’s disease risk.  Guest: Leonardo Iaccarino, PhD, University of California San Francisco Memory and Aging Center

Managing Inappropriate Sexual Behavior in Alzheimer’s Disease

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Inappropriate sexual behavior is a common yet rarely discussed symptom in individuals with dementia. Author Elizabeth Marcus writes about her personal experience with her father’s behavioral changes in her new book, Don’t Say a Word!: A Daughter’s Two Cents. Elizabeth shares what she learned caring for her father, as well as advice for caregivers responding to the symptoms. Neurologist Dr. Martin Samuels offers background on changes in the brain that can cause inappropriate sexual behavior and other personality shifts that are common in people with dementia. Guest: Elizabeth Marcus, author; Martin Allen Samuels, MD, Brigham and Women's Hospital

Being Patient Translates Alzheimer’s Disease Science for the General Public

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Being Patient is an online news source dedicated to providing research news, caregiver information and resources related to Alzheimer's disease. Being Patient founder Deborah Kan discusses how her personal experiences led her to develop the website, as well as how online resources and communities can help empower individuals affected by memory loss. Guest: Deborah Kan, journalist, founder of beingpatient.com

How Society Can Improve Care for People with Alzheimer’s Disease and Related Dementias

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Dr. Jason Karlawish discusses society’s role in addressing care for individuals with memory loss, as well as current stigmas around Alzheimer’s disease, Wealthcare, and his cautious optimism for the future of Alzheimer’s disease research and care. This is the final episode in our four-part series with Dr. Karlawish on his new book, The Problem of Alzheimer's: How Science, Culture, and Politics Turned a Rare Disease Into a Crisis and What We Can Do About It. Guest: Jason Karlawish, MD, co-director, Penn Memory Center